- Description
- Why AHA & Fruit Enzymes Matter
- Ingredients
- Watch & Learn
- Dr. Bryan
- FAQs
- Clinical Studies
Description
What makes the Age-Defiance Gel Cleanser different?
Most cleansers aim for a surface clean. Our Age-Defiance Gel Cleanser goes further, infusing powerful skin science into your first routine step. This age-defying blend of fruit, flower, and plant extracts gently cleanses. Alpha-Hydroxy Acid (AHA) from passionflower, lemon, grape, and pineapple extracts (Glycolic, Lactic, Citric, Malic, Tartaric acids) encourages cell turnover and oxygenates skin cells. Antioxidants like Vitamin C and Green Tea brighten and protect, while Aloe Vera, Algae Extract, and Kola Nut Extract soothe. This gel cleanser purifies and invigorates, leaving skin soft, smooth, and receptive—never stripped. The result: clearer, brighter, and more refined skin.
Results You Can See:
- Immediately: Skin feels fresh, balanced, and comfortable—no residue or tightness
- After 1 week: Visible improvement in clarity, smoothness, and radiance
- With continued use: A more even tone and refined look of pores for a youthful-looking glow
How to Use for Best Results:
- Use morning and night
- Apply 2-3 pumps in the palm of your hand and then apply to damp skin
- Gently massage over face and neck for 30–60 seconds
- Rinse thoroughly with lukewarm water and pat dry
- Follow with N1o1 Nitric Oxide Activating Age-Defiance Serum and Age-Defiance Face Cream and Eye Cream for maximum benefits
What to Expect
A cushiony gel that lathers lightly, rinses clean, and leaves skin soft. With consistent daily use, most users report fresher tone, smoother texture, and a healthy-looking glow within the first few weeks.
Boost your skin health from within with N1o1 Nitric Oxide Lozenges. These easy to dissolve lozenges enhance microcirculation, improve oxygen and nutrient delivery, and strengthen your skin’s barrier.
Why AHA & Fruit Enzymes Matter
Why AHA & Fruit Enzymes Matter
This formula is enriched with AHA (alpha hydroxy acids), including glycolic acid, and natural fruit enzymes that work together to deliver gentle, effective exfoliation every time you cleanse. Our thoughtfully balanced blend helps loosen and lift away dull surface cells, revealing smoother, softer, and more radiant skin beneath. Unlike harsh scrubs, AHAs and fruit enzymes encourage cell turnover without irritation, improving texture and clarity. With regular use, you’ll notice a brighter, fresher complexion and a visibly refined appearance—while laying the groundwork for the rest of your skincare routine to work even better.
Ingredients
Key Ingredients
Multi-AHA Complex (Glycolic, Lactic, Citric, Tartaric, Malic Acids):
Gently exfoliates to smooth texture, refine the look of pores, and brighten dullness for a fresh, even-looking tone.
Multi-AHA Complex (Glycolic, Lactic, Citric, Tartaric, Malic Acids):
Gently exfoliates to smooth texture, refine the look of pores, and brighten dullness for a fresh, even-looking tone.
Fruit Enzymes & Extracts (Pineapple, Passionfruit, Grape):
Enzyme-assisted exfoliation helps lift surface buildup while antioxidants support a clearer, more radiant complexion.
Fruit Enzymes & Extracts (Pineapple, Passionfruit, Grape):
Enzyme-assisted exfoliation helps lift surface buildup while antioxidants support a clearer, more radiant complexion.
Hydrating Humectants (Glycerin, Aloe Juice):
Draw in and retain moisture for a comfortable, non-stripping cleanse.
Hydrating Humectants (Glycerin, Aloe Juice):
Draw in and retain moisture for a comfortable, non-stripping cleanse.
Soothing Botanicals (Green Tea, Algae, Honeysuckle):
Help calm and condition skin for a soft, balanced feel after rinsing.
Soothing Botanicals (Green Tea, Algae, Honeysuckle):
Help calm and condition skin for a soft, balanced feel after rinsing.
Vitamin C (Ascorbic Acid):
Antioxidant support to defend against environmental stressors and promote post-cleanse luminosity.
Vitamin C (Ascorbic Acid):
Antioxidant support to defend against environmental stressors and promote post-cleanse luminosity.
Skin-Conditioning Polymers:
Create a soft, cushiony lather and leave skin feeling smooth.
Skin-Conditioning Polymers:
Create a soft, cushiony lather and leave skin feeling smooth.
Water:
Provides a clean base for optimal delivery and easy rinse-off.
Water:
Provides a clean base for optimal delivery and easy rinse-off.
Full Ingredient List:
Water, Ammonium Lauryl Sulfate, Glycerin, Hydroxyethylcellulose, Potassium Oleate, Potassium Cocoate, Glycolic Acid, Lactic Acid, Citric Acid, Tartaric Acid, Malic Acid, Passiflora Edulis Fruit Extract, Ananas Sativus (Pineapple) Fruit Extract, Vitis Vinifera (Grape) Fruit Extract, Aloe Barbadensis Leaf Juice, Algae Extract, Ascorbic Acid, Camellia Oleifera Leaf Extract, Lonicera Caprifolium (Honeysuckle) Flower Extract, Lonicera Japonica (Honeysuckle) Flower Extract, Propanediol, Cola Acuminata Seed Extract, Polysorbate 20, Fragrance, Alcohol Denat., Potassium Citrate, Tetrasodium EDTA
Full Ingredient List:
Water, Ammonium Lauryl Sulfate, Glycerin, Hydroxyethylcellulose, Potassium Oleate, Potassium Cocoate, Glycolic Acid, Lactic Acid, Citric Acid, Tartaric Acid, Malic Acid, Passiflora Edulis Fruit Extract, Ananas Sativus (Pineapple) Fruit Extract, Vitis Vinifera (Grape) Fruit Extract, Aloe Barbadensis Leaf Juice, Algae Extract, Ascorbic Acid, Camellia Oleifera Leaf Extract, Lonicera Caprifolium (Honeysuckle) Flower Extract, Lonicera Japonica (Honeysuckle) Flower Extract, Propanediol, Cola Acuminata Seed Extract, Polysorbate 20, Fragrance, Alcohol Denat., Potassium Citrate, Tetrasodium EDTA
Watch & Learn
Glow confidently and embrace timeless skin with the N1o1 Age-Defiance Gel Cleanser—your first step to a radiant, youthful complexion. Watch this video to learn how to get the best results:
Susan Shaffer
President and Co-Founder of N1o1 Nitric Oxide
Dr. Bryan
MEET THE FOUNDER
Dr. Nathan Bryan: A Leading Authority on Nitric Oxide
Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.
A Pioneer in Nitric Oxide Science
With over 20 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.
A Pioneer in Nitric Oxide Science
With over 20 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.
Clinically Backed & Scientifically Proven
His discoveries have shaped the field of Nitric Oxide therapy, leading to cutting-edge solutions like the Age-Defiance Gel Cleanser you’re about to experience.
Clinically Backed & Scientifically Proven
His discoveries have shaped the field of Nitric Oxide therapy, leading to cutting-edge solutions like the Age-Defiance Gel Cleanser you’re about to experience.
On a Mission to Improve Lives
Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.
On a Mission to Improve Lives
Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.
FAQs
Storage and guarantee
Store in a cool, dry place and use by the date on the package. Backed by our 60-day money-back guarantee.
Clinical note
For optimal cosmetic results, follow daily cleansing with the clinically proven N1o1 Nitric Oxide Activating Age-Defiance Serum. Doctor-formulated by Dr. Nathan S. Bryan, clinical studies show this serum improves skin tone, texture, and reduces fine lines.
Ready to elevate your first step? Add the N1o1 Age-Defiance Gel Cleanser to your routine and unlock a brighter, smoother, more youthful-looking complexion.
Clinical Studies
[1] Dual Effects of Alpha-Hydroxy Acids on the Skin
PubMed
Sheau-Chung Tang, Jen-Hung Yang
Department of Biochemistry, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan
Department of Medical Research, Buddhist Tzu Chi General Hospital, Hualien 97004, Taiwan
Department of Dermatology, Buddhist Tzu Chi General Hospital, Hualien 97004, Taiwan
Download the PDF
[2] Topical AHA in Dermatology: Formulations, Mechanisms of Action, Efficacy, and Future Perspectives
MDPI
Kanwarpreet Karwal, Ilya Mukovozov
Faculty of Medicine, Schulich School of Medicine and Dentistry, London, ON N6A 5C1, Canada
Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC V5Z 4E8, Canada
Download the PDF
[3] Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory TNF‐alpha in human skin explants
PubMed
Mridvika Narda, Carles Trullas, Anthony Brown, Jaime Piquero‐Casals, Corinne Granger, Gabriella Fabbrocini
Innovation and Development, ISDIN, Barcelona, Spain
External consultant to ISDIN, Barcelona, Spain
Dermik Clinica Dermatologica Multidisciplinar, Barcelona, Spain
Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Frederico II, Naples, Italy
Download the PDF
