Age-Defiance Eye Cream (wholesale)

Revitalize Your Eyes with the Power of Nitric Oxide

Developed by Dr. Nathan S. Bryan, our Nitric Oxide Boosting Age-Defiance Eye Cream is specifically designed to target the delicate skin around your eyes. By improving microcirculation at the cellular level, this advanced formula reduces the appearance of fine lines, wrinkles, puffiness, and dark circles. Infused with collagen boosters, peptides, hyaluronic acid and ceramides, it hydrates deeply while enhancing firmness and elasticity. The result? Brighter, smoother, and more youthful-looking eyes every day.

  • Potentiates nitric oxide production to support healthy, radiant skin.
  • Reduces puffiness and dark circles for a refreshed appearance. 
  • Visibly smooths fine lines and wrinkles around the eyes.
  • Improves skin texture and elasticity, restoring youthful firmness.
  • Deeply hydrates and nourishes the delicate under-eye area.

Pricing visible to wholesalers only

SKU: NEC15-2-WHO Category:

Description

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Treat the Delicate Eye Area

Healthy nitric oxide levels are essential for optimal microcirculation, which is key to maintaining a vibrant, youthful appearance. As we age, natural nitric oxide production declines, leading to visible signs of aging like dark circles, puffiness, and fine lines.

N1o1’s Nitric Oxide Boosting Age-Defiance Eye Cream works synergistically with our Nitric Oxide Activating Serum to restore nitric oxide levels, improving blood flow and oxygen delivery to the skin. This innovative process helps reduce puffiness, brighten dark circles, and smooth fine lines, leaving your eyes looking refreshed and rejuvenated.

What Makes the Nitric Oxide Boosting Age-Defiance Eye Cream Unique?

Unlike most eye creams that only address surface-level concerns, N1o1’s formula works at the cellular level to transform your skin from within. Backed by Nobel Prize-winning nitric oxide science, this eye cream is expertly crafted with four powerful anti-aging ingredients to target and revitalize the delicate under-eye area:

  • Nitric Oxide: The foundation for healthy, radiant skin.
  • Complex Peptide Formula: Rejuvenates and restores youthful firmness.
  • Hyaluronic Acid: Hydrates and locks in moisture for smoother, plumper skin.
  • Ceramides: Strengthens the skin’s natural barrier to retain moisture and defend against environmental damage.

Experience the visible transformation as our advanced formula revitalizes your under-eye area, reducing the appearance of wrinkles, puffiness, and dark circles.

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How To Use

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How to Use for Optimal Results

For brighter, smoother, and more youthful-looking eyes, use the Nitric Oxide Boosting Age-Defiance Eye Cream twice daily.

Your Morning & Night Ritual:

  • Apply a small amount to clean, dry skin around the eyes.
  • Gently pat with your ring finger until fully absorbed.

Storage:
To maintain potency, store in a cool, dark place and use before the expiration date printed on the package.

What to Expect

Our formula works at a cellular level to address visible signs of aging around the eyes. By improving microcirculation with nitric oxide, it reduces puffiness, brightens dark circles, and smooths fine lines. With consistent use, you’ll notice a firmer, more youthful appearance.

Pairs effectively with:

  • Age-Defiance Gel Cleanser
  • Nitric Oxide Activating Age-Defiance Serum
  • Nitric Oxide Age-Defiance Face Cream

Within 30 Days:
Most users report visible improvements in the appearance of dark circles, puffiness, and fine lines within the first 30 days of consistent use.

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Why Nitric Oxide Matters

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Why Nitric Oxide Matters for Your Skin

Nitric oxide is a vital molecule that enhances microcirculation, delivering oxygen and nutrients to your skin cells. This improved blood flow helps reduce puffiness, brighten dark circles, and smooth fine lines. By supporting cellular repair, nitric oxide revitalizes the delicate under-eye area, leaving your skin looking healthier, stronger, and more radiant.

Ingredients

Science Backed Ingredients

Our formula blends advanced scientific ingredients with nourishing botanicals to deliver age-defying results while supporting skin health. It hydrates, smooths, and brightens the under-eye area, leaving your skin refreshed and rejuvenated.

Nitric Oxide–Activating Component (Sodium Nitrite)

Boosts circulation to brighten and revitalize the skin.

Sodium-Nitrite-1
Sodium-Nitrite-1

Nitric Oxide–Activating Component (Sodium Nitrite)

Boosts circulation to brighten and revitalize the skin.

Multi-Peptide Complex (Palmitoyl Tripeptide-1, -7, -5)

Improves firmness and reduces the look of fine lines.

Multi-Peptide-Complex-1
Multi-Peptide-Complex-1

Multi-Peptide Complex (Palmitoyl Tripeptide-1, -7, -5)

Improves firmness and reduces the look of fine lines.

Ceramide Complex (Ceramide NP, NS, EOS, EOP, AP)

Reinforces the skin barrier for improved hydration and resilience.

Ceramide-Complex
Ceramide-Complex

Ceramide Complex (Ceramide NP, NS, EOS, EOP, AP)

Reinforces the skin barrier for improved hydration and resilience.

Advanced Hydration Matrix (Sodium Hyaluronate, Sodium PCA, Tremella Fuciformis Extract)

Locks in moisture for a plumper appearance.

Advanced-Hydration-Matrix
Advanced-Hydration-Matrix

Advanced Hydration Matrix (Sodium Hyaluronate, Sodium PCA, Tremella Fuciformis Extract)

Locks in moisture for a plumper appearance.

Nourishing Lipids & Emollients (Sunflower Seed Oil, Squalane, Garcinia Indica Seed Butter, Coconut Oil)

Soften skin and support its natural barrier.

Nourishing-Lipids-Emollients
Nourishing-Lipids-Emollients

Nourishing Lipids & Emollients (Sunflower Seed Oil, Squalane, Garcinia Indica Seed Butter, Coconut Oil)

Soften skin and support its natural barrier.

Botanical Antioxidants & Soothers (Green Tea, Cucumber, Dunaliella Salina Extract)

Calm and protect the delicate under-eye area.

Botanical-Antioxidants-Soothers
Botanical-Antioxidants-Soothers

Botanical Antioxidants & Soothers (Green Tea, Cucumber, Dunaliella Salina Extract)

Calm and protect the delicate under-eye area.

Coconut-Derived Actives (Coconut Liquid Endosperm & Fruit Juice)

Deliver essential nutrients and hydration.

Coconut-Derived-Actives
Coconut-Derived-Actives

Coconut-Derived Actives (Coconut Liquid Endosperm & Fruit Juice)

Deliver essential nutrients and hydration.

Skin-Soothing Agents (Chrysin, Panthenol, Biosaccharide Gum-1)

Reduce puffiness and soothe the under-eye area.

Skin-Soothing-Agents
Skin-Soothing-Agents

Skin-Soothing Agents (Chrysin, Panthenol, Biosaccharide Gum-1)

Reduce puffiness and soothe the under-eye area.

Full Ingredient List

Water, Helianthus Annuus (Sunflower) Seed Oil, Cetearyl Alcohol, Glyceryl Stearate SE, Squalane, Dimethicone, Garcinia Indica Seed Butter, Ceteareth-20, Glycerin, Sodium Nitrite, Magnesium Aluminum Silicate, Sodium PCA, Palmitoyl Tripeptide-5, Coconut Alkanes, Propanediol, Polyacrylamide, Sodium Hyaluronate, Tremella Fuciformis (Mushroom) Extract, Palmitoyl Tripeptide-1, Dicaprylyl Ether,N-Hydroxysuccinimide, Camellia Sinensis Leaf Extract, Cetyl Alcohol, Palmitoyl Tetrapeptide-7, Cetyl Esters, Dunaliella Salina Extract, Cocos Nucifera (Coconut) Oil, C13-14 Isoparaffin, Cucumis Sativus (Cucumber) Fruit Extract, Biosaccharide Gum-1, Ceteareth-25, Steareth-20, Laureth-7, Behenic Acid, Phenoxyethanol, Cholesterol, Cocos Nucifera (Coconut) Liquid Endosperm, Ceramide NP, Ceramide NS, Ceramide EOS, Ceramide EOP, Ceramide AP, Chrysin, Cocos Nucifera (Coconut) Fruit Juice, Caprooyl Phytosphingosine, Caprooyl Sphingosine, Caprylyl Glycol, Panthenol, Coco-Caprylatel Caprate, Lecithin, Titanium Dioxide.

N1o1-Nitric-Oxide-Age-Defiance-Eye-Cream-Ingredients
N1o1-Nitric-Oxide-Age-Defiance-Eye-Cream-Ingredients

Full Ingredient List

Water, Helianthus Annuus (Sunflower) Seed Oil, Cetearyl Alcohol, Glyceryl Stearate SE, Squalane, Dimethicone, Garcinia Indica Seed Butter, Ceteareth-20, Glycerin, Sodium Nitrite, Magnesium Aluminum Silicate, Sodium PCA, Palmitoyl Tripeptide-5, Coconut Alkanes, Propanediol, Polyacrylamide, Sodium Hyaluronate, Tremella Fuciformis (Mushroom) Extract, Palmitoyl Tripeptide-1, Dicaprylyl Ether,N-Hydroxysuccinimide, Camellia Sinensis Leaf Extract, Cetyl Alcohol, Palmitoyl Tetrapeptide-7, Cetyl Esters, Dunaliella Salina Extract, Cocos Nucifera (Coconut) Oil, C13-14 Isoparaffin, Cucumis Sativus (Cucumber) Fruit Extract, Biosaccharide Gum-1, Ceteareth-25, Steareth-20, Laureth-7, Behenic Acid, Phenoxyethanol, Cholesterol, Cocos Nucifera (Coconut) Liquid Endosperm, Ceramide NP, Ceramide NS, Ceramide EOS, Ceramide EOP, Ceramide AP, Chrysin, Cocos Nucifera (Coconut) Fruit Juice, Caprooyl Phytosphingosine, Caprooyl Sphingosine, Caprylyl Glycol, Panthenol, Coco-Caprylatel Caprate, Lecithin, Titanium Dioxide.

Dr. Bryan

MEET THE FOUNDER

Dr. Nathan Bryan: A Leading Authority on Nitric Oxide

Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.

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A Pioneer in Nitric Oxide Science

With over 20 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.

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A Pioneer in Nitric Oxide Science

With over 20 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.

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Clinically Backed & Scientifically Proven

His discoveries have shaped the field of Nitric Oxide therapy, leading to cutting-edge solutions like the Nitric Oxide Boosting Age-Defiance Eye Cream you’re about to experience.

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Clinically Backed & Scientifically Proven

His discoveries have shaped the field of Nitric Oxide therapy, leading to cutting-edge solutions like the Nitric Oxide Boosting Age-Defiance Eye Cream you’re about to experience.

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On a Mission to Improve Lives

Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.

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On a Mission to Improve Lives

Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.

About-Dr-Nathan-Bryan-e1760108713984

FAQs

Ready to unlock your eyes’ full potential?

Add the N1o1 Nitric Oxide Boosting Age-Defiance Eye Cream to your routine and reveal brighter, smoother, and more youthful-looking eyes.

Studies

[1] Dermal Nitrite Application Enhances Global Nitric Oxide Availability: New Therapeutic Potential for Immunomodulation?
Journal of Investigative Dermatology
Maria Francisca Garcia-Saura, Bernadette O. Fernandez, Brian P. McAllister, David R. Whitlock, William W. Cruikshank, Martin Feelisch
Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK
The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, USA
Nitroceutic LLC, Dover, Massachusetts, USA
Download the PDF

[2] Nitric oxide therapy for dermatologic disease
PubMed
Brandon L Adler, Adam J Friedman
Department of Medicine (Division of Dermatology), Albert Einstein College of Medicine, Bronx, NY, USA
Department of Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA
George Washington School of Medicine & Health Sciences, Washington, DC, USA
Download the PDF

[3] Nitric Oxide Signal Transduction and Its Role in Skin Sensitization
PubMed
Jong Hun Kim, Min Sik Choi
Department of Food Science and Biotechnology, and Institute for Basic Sciences, Sungshin Women’s University, Seoul 01133, Republic of Korea
Lab of Pharmacology, College of Pharmacy, Dongduk Women’s University, Seoul 02748, Republic of Korea
Download the PDF

[4] Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review
PubMed
Andrada Pintea, Andrei Manea, Cezara Pintea, Robert-Alexandru Vlad, Magdalena Bîrsan, Paula Antonoaea, Emöke Margit Rédai, Adriana Ciurba
Medicine and Pharmacy Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania
Pharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures
Department of Drug Industry and Pharmaceutical Biotechnology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
Download the PDF

[5] Anti-Wrinkle Benefits of Peptides Complex Stimulating Skin Basement Membrane Proteins Expression
PubMed
Sekyoo Jeong, Seokjeong Yoon, Sungwoo Kim, Juyeon Jung, Myungho Kor, Kayoung Shin, Chaejin Lim, Hyo Sun Han, Haekwang Lee, Kyeong-Yong Park, Jinwan Kim, Hwa Jee Chung, Hyun Jung Kim
Research Division, Incospharm Corporation, Daejeon 34036, Korea
P&K Skin Research Center Company Limited, Seoul 07236, Korea
Research Division, Cha Meditech Corporation, Daejeon 34025, Korea
CHA Bio F&C, Seongnam 13488, Korea
Department of Dermatology, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea
See The Study

[6] A review of the efficacy of popular eye cream ingredients
PubMed
Hanin Hamie, Reem Yassine, Rajaa Shoukfeh, Dilara Turk, Farhan Huq, Meena Moossavi
College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan
School of Medicine, Wayne State University, Detroit, Michigan
Department of Dermatology, Wayne State University, Detroit, Michigan
See The Study