This is the first and only serum in the world that generates nitric oxide directly on your skin’s surface. Its unique dual-chamber system activates upon use, delivering a fresh, potent dose every time to revitalize your skin’s appearance in a way no other product can.

Nitric oxide is a vital molecule that supports circulation. By improving localized microcirculation, it helps deliver oxygen and nutrients to skin cells, which in turn supports the look of healthy collagen, refines skin texture, and promotes a brighter, more even-toned complexion.

The brief pink flush and warming sensation you may feel is a visible sign that the serum is working. This indicates the generation of nitric oxide and an increase in local circulation, which is a normal and temporary effect that typically fades within a few minutes.

The N1o1 Nitric Oxide Activating Serum is formulated to be gentle and effective for all skin types, including sensitive, oily, dry, and combination skin. Its purpose is to restore healthy skin function, making it a universal tool for anyone seeking to address the visible signs of aging.

Use it twice daily, morning and night, on clean skin. Dispense one pump from each chamber, mix them in your palm, and apply a thin layer to your face and neck. A single bottle provides approximately 70 applications.

While many users notice an immediate glow, consistent use is key for long-term benefits. Most people report visible improvements in skin tone, texture, and the appearance of fine lines and wrinkles within the first 30 days of daily use.

Yes. Our serum contains 20% Vitamin C, so you won’t need a separate one. Apply N1o1 first on clean, dry skin, wait 1-2 minutes for it to fully absorb, and then you can layer other products like moisturizers or your nightly retinoid on top.

Yes, the N1o1 Nitric Oxide Activating Age-Defiance Serum is supported by multiple clinical studies that demonstrate its effectiveness in improving the appearance of skin tone, texture, reducing the visibility of fine lines and wrinkles, and boasts a 100% satisfaction rating among users in the clinical studies. Regular use in these studies led to noticeable cosmetic improvements for most participants.

We are committed to creating powerful skincare without compromise. The N1o1 serum is proudly vegan, cruelty-free, gluten-free, and non-GMO.

Store your serum in a cool, dark place to protect its potency, and be sure to use it before the expiration date on the package. We are confident you’ll love the results, which is why every purchase is backed by our 60-day money-back guarantee.