Age-Defiance Face Cream (wholesale)
Restore Youthful Radiance with Nitric Oxide Science
Developed by Dr. Nathan S Bryan, our Nitric Oxide Boosting Age-Defiance Face Cream replenishes skin at the cellular level to improve microcirculation, promoting a brighter, smoother, and more even complexion. Formulated with collagen boosters, peptides, and Epidermal Growth Factor (EGF) to stimulate cell growth, this cream provides deep hydration while visibly reducing fine lines and wrinkles. Designed to enhance skin firmness and texture, it leaves your skin soft, refreshed, and rejuvenated every day.
Description
Revitalize and Renew Your Skin
Healthy nitric oxide levels are crucial for optimal microcirculation and a radiant complexion. As we age, natural nitric oxide production declines, affecting skin tone, texture, and luminosity.
N1o1’s Nitric Oxide Age-Defiance Face Cream helps potentiate the nitric oxide production when used in combination with N1o1 nitric oxide activating serum. This unique process supports improved microcirculation for a brighter, smoother, and firmer-looking complexion. By harnessing Nobel Prize-winning nitric oxide science in a premium, clean formula, our cream addresses visible aging at its source. The result is visibly revitalized skin with a healthy, youthful glow.
What makes the Nitric Oxide Age-Defiance Face Cream unique?
Most face creams only work on the skin’s surface. N1o1 goes further, using the revitalizing benefits of nitric oxide to visibly rejuvenate your skin. Backed by Nobel Prize-winning science, our formula works at the cellular level to transform your skin from within. Unleash your skin’s youthful potential with our advanced Age Defiance Face Cream, expertly formulated with three powerful anti-aging ingredients designed to specifically target and transform problem skin.
- Nitric Oxide: The fundamental key to radiant, beautiful skin.
- Complex Peptide Formula: Essential building blocks that rejuvenate and visibly restore your complexion.
- Epidermal Growth Factor (EGF): Actively boosts natural collagen and elastin production for enhanced firmness and resilience.
Experience the visible transformation as our advanced formula revitalizes your skin’s youthful appearance from within.
- Reduce the appearance of wrinkles and dark spots for a rejuvenated look.
- Improve skin texture and tone, creating a smoother, more even complexion.
- Deliver deep hydration and essential protection to energize your skin.
- Stimulate collagen production and natural anti-aging processes.
- Activate the skin’s water management system for long-lasting moisture.
- Revitalize elasticity for a firmer, lifted appearance.
Strengthen the skin barrier, promoting healthier, more resilient skin cells.
How To Use
How to Use for Optimal Results
For a visibly smoother, brighter, and more youthful-looking complexion, use the Nitric Oxide Activating Age-Defiance Face Cream twice daily.
Your Morning & Night Ritual:
- Apply daily, AM and PM to clean, dry skin.
Storage:
To protect the formula’s potency, store your face cream in a cool, dark place and use it before the expiration date printed on the package.
What to Expect
Our formula works at a cellular level to address the signs of aging by reducing the appearance of fine lines and wrinkles and enhancing your skin tone for a more even complexion. It improves skin circulation with nitric oxide, rejuvenates with advanced complex peptides, and stimulates collagen and elastin production with Epidermal Growth Factor (EGF), promoting a youthful, glowing appearance.
Pairs effectively with N1o1 Gel Cleanser, Nitric Oxide Age-Defiance Serum, and Eye Cream.
Within 30 Days: Visible Transformation
Consistency is key to unlocking lasting results. With consistent morning and night use, most users report seeing noticeable improvements in their skin’s appearance within the first 30 days. Look forward to a visibly brighter and more even skin tone, refined texture, and enhanced clarity for a healthier, more youthful look.
- Nitric Oxide: The fundamental key to radiant, beautiful skin.
- Complex Peptide Formula: Essential building blocks that rejuvenate and visibly restore your complexion.
- Epidermal Growth Factor (EGF): Actively boosts natural collagen and elastin production for enhanced firmness and resilience.
Why Nitric Oxide
Why Nitric Oxide Matters for Your Skin
Our formula uses nitric oxide to bring new life to your skin. As a crucial molecule, nitric oxide enhances microcirculation, increasing the flow of oxygen and essential nutrients to your skin cells. This improved blood flow helps combat dullness, leading to a brighter and more radiant complexion. By supporting cellular repair, nitric oxide smooths skin texture, calms inflammation, and balances your skin tone. With consistent use, your skin will look and feel healthier, stronger, and perfectly prepared for the rest of your skincare regimen.
Ingredients
Science Backed Ingredients
Our formula unites advanced scientific ingredients with nourishing botanicals to deliver comprehensive age-defying results while maintaining skin health and comfort.
Nitric Oxide–Activating Component (Sodium Nitrite)
The key part of our dual-chamber system that helps generate nitric oxide on the skin's surface upon application.
Nitric Oxide–Activating Component (Sodium Nitrite)
The key part of our dual-chamber system that helps generate nitric oxide on the skin's surface upon application.
Epidermal Growth Factor (EGF) & Growth Factors (sh-Oligopeptide-1/2, sh-Polypeptide-1/9/11)
This blend of skin-similar proteins helps the complexion look smoother and more refined.
Epidermal Growth Factor (EGF) & Growth Factors (sh-Oligopeptide-1/2, sh-Polypeptide-1/9/11)
This blend of skin-similar proteins helps the complexion look smoother and more refined.
Multi-Peptide Complex (Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7)
A targeted peptide duo that supports the look of youthful firmness and elasticity.
Multi-Peptide Complex (Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7)
A targeted peptide duo that supports the look of youthful firmness and elasticity.
Advanced Hydration Matrix (Glycerin, Sodium PCA, Sodium Hyaluronate)
Draws in and retains moisture to give skin a visibly plumper and more hydrated appearance.
Advanced Hydration Matrix (Glycerin, Sodium PCA, Sodium Hyaluronate)
Draws in and retains moisture to give skin a visibly plumper and more hydrated appearance.
Nourishing Lipids & Emollients (Grape Seed Oil, Squalane, Olive-derived lipids)
Reinforces skin comfort and promotes a soft, smooth-to-the-touch feel.
Nourishing Lipids & Emollients (Grape Seed Oil, Squalane, Olive-derived lipids)
Reinforces skin comfort and promotes a soft, smooth-to-the-touch feel.
Botanical Antioxidants & Soothers (Arnica, Hops, Rosemary & Lemon Bioflavonoids)
Acts as the pure, clean base for our advanced formula, ensuring optimal delivery of all active ingredients.
Botanical Antioxidants & Soothers (Arnica, Hops, Rosemary & Lemon Bioflavonoids)
Acts as the pure, clean base for our advanced formula, ensuring optimal delivery of all active ingredients.
Full Ingredient List
Water, Vitis Vinifera (Grape) Seed Oil, Cetearyl Alcohol, Glyceryl Stearate SE, Squalane, Ceteareth-20, Glycerin, Sodium Nitrite, Magnesium Aluminum Silicate, Sodium PCA, Sodium Hyaluronate, Butylene Glycol, Polyacrylamide, Palmitoyl Tripeptide-1, Lecithin, Acetyl Glutamine, Palmitoyl tetrapeptide-7, sh-Oligopeptide-1, sh-Oligopeptide-2, Arnica Montana Flower Extract, Cetyl Esters, Humulus Lupulus (Hops) Extract, sh-Polypeptide-1, sh-Polypeptide-9, Equisetum Hyemale Extract, sh-Polypeptide-11, Pinus Strobus Cone Extract, Lecithin, Bacillus/Folic Acid Ferment Filtrate Extract, Hydrogenated Ethylhexyl Olivate, Hydrogenated Olive Oil Unsaponifiables, Citrus Limon (Lemon Bioflavonoids) Peel Extract, Rosmarinus Officinalis (Rosemary) Extract, C13-14 Isoparaffin, Phenoxyethanol, Cetyl Alcohol, 1,2-Hexanediol, Caprylyl Glycol, Laureth-7, Polysorbate 20, Carbomer, Titanium Dioxide.
Full Ingredient List
Water, Vitis Vinifera (Grape) Seed Oil, Cetearyl Alcohol, Glyceryl Stearate SE, Squalane, Ceteareth-20, Glycerin, Sodium Nitrite, Magnesium Aluminum Silicate, Sodium PCA, Sodium Hyaluronate, Butylene Glycol, Polyacrylamide, Palmitoyl Tripeptide-1, Lecithin, Acetyl Glutamine, Palmitoyl tetrapeptide-7, sh-Oligopeptide-1, sh-Oligopeptide-2, Arnica Montana Flower Extract, Cetyl Esters, Humulus Lupulus (Hops) Extract, sh-Polypeptide-1, sh-Polypeptide-9, Equisetum Hyemale Extract, sh-Polypeptide-11, Pinus Strobus Cone Extract, Lecithin, Bacillus/Folic Acid Ferment Filtrate Extract, Hydrogenated Ethylhexyl Olivate, Hydrogenated Olive Oil Unsaponifiables, Citrus Limon (Lemon Bioflavonoids) Peel Extract, Rosmarinus Officinalis (Rosemary) Extract, C13-14 Isoparaffin, Phenoxyethanol, Cetyl Alcohol, 1,2-Hexanediol, Caprylyl Glycol, Laureth-7, Polysorbate 20, Carbomer, Titanium Dioxide.
Watch & Learn
Dr. Bryan
MEET THE FOUNDER
Dr. Nathan Bryan: A Leading Authority on Nitric Oxide
Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.
A Pioneer in Nitric Oxide Science
With over 20 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.
A Pioneer in Nitric Oxide Science
With over 20 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.
Clinically Backed & Scientifically Proven
His discoveries have shaped the field of Nitric Oxide therapy, leading to cutting-edge solutions like the Age-Defiance Face Cream you’re about to experience.
Clinically Backed & Scientifically Proven
His discoveries have shaped the field of Nitric Oxide therapy, leading to cutting-edge solutions like the Age-Defiance Face Cream you’re about to experience.
On a Mission to Improve Lives
Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.
On a Mission to Improve Lives
Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.
FAQs
Clinical note
For optimal cosmetic results, follow daily cleansing with the clinically proven N1o1 Nitric Oxide Activating Age-Defiance Serum before applying the face cream. Doctor-formulated by Dr. Nathan S. Bryan, clinical studies show this serum improves skin tone, texture, and reduces fine lines.
Ready to unlock your skin’s full potential? Add the N1o1 Age-Defiance Face Cream to your routine and reveal a brighter, smoother, more youthful-looking complexion.
Studies
[1] Nitric oxide therapy for dermatologic disease
PubMed
Brandon L Adler, Adam J Friedman
Department of Medicine (Division of Dermatology), Albert Einstein College of Medicine, Bronx, NY, USA
Department of Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA
George Washington School of Medicine & Health Sciences, Washington, DC, USA
Download the PDF
[2] Nitric Oxide Signal Transduction and Its Role in Skin Sensitization
PubMed
Jong Hun Kim, Min Sik Choi
Department of Food Science and Biotechnology, and Institute for Basic Sciences, Sungshin Women’s University, Seoul 01133, Republic of Korea
Lab of Pharmacology, College of Pharmacy, Dongduk Women’s University, Seoul 02748, Republic of Korea
Download the PDF
[3] The use of epidermal growth factor in dermatological practice
PubMed
Sun Hye Shin, Young Gue Koh, Woo Geon Lee, Joon Seok, Kui Young Park
Department of Dermatology, Chung‐Ang University College of Medicine, Seoul, South Korea
Download the PDF
[4] Epidermal Growth Factor in Aesthetics and Regenerative Medicine: Systematic Review
PubMed
Blanca Miller-Kobisher, Dubraska V Suárez-Vega, Gladys J Velazco de Maldonado
Pan-American Institute of Scientific Professionals (IPPC), México City, Mexico
Department of Investigation, Dental Research Center, University of Los Andes (ULA), Mérida, Venezuela
Department of Restorative Dentistry, Dental Research Center, University of Los Andes (ULA), Mérida, Venezuela
Download the PDF
[5] Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review
PubMed
Andrada Pintea, Andrei Manea, Cezara Pintea, Robert-Alexandru Vlad, Magdalena Bîrsan, Paula Antonoaea, Emöke Margit Rédai, Adriana Ciurba
Medicine and Pharmacy Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania
Pharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures
Department of Drug Industry and Pharmaceutical Biotechnology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
See The Study
[6] Anti-Wrinkle Benefits of Peptides Complex Stimulating Skin Basement Membrane Proteins Expression
PubMed
Sekyoo Jeong, Seokjeong Yoon, Sungwoo Kim, Juyeon Jung, Myungho Kor, Kayoung Shin, Chaejin Lim, Hyo Sun Han, Haekwang Lee, Kyeong-Yong Park, Jinwan Kim, Hwa Jee Chung, Hyun Jung Kim
Research Division, Incospharm Corporation, Daejeon 34036, Korea
P&K Skin Research Center Company Limited, Seoul 07236, Korea
Research Division, Cha Meditech Corporation, Daejeon 34025, Korea
CHA Bio F&C, Seongnam 13488, Korea
Department of Dermatology, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea
See The Study
