CardioSmile Nitric Oxide Toothpaste
LIMITED TIME RELEASE
Boost your oral and systemic health with the world’s first nitric oxide-enhancing toothpaste for peak oral wellness. Free from fluoride and harmful toxins, it supports your mouth’s natural nitric oxide production. Developed by Dr. Nathan Bryan, Biomedical Scientist.
- Boosts Your Mouth’s Natural Microbiome
- Freshens Breath
- Remineralizes Enamel
- Fluoride-Free Formula
- Enhances Gum Health
Maximum of 2 per order.
Not available for resell. For personal use only.
Description
Healthier Gums. Brighter Smiles. More Confidence.
Your oral health thrives on strong circulation, healthy gums, optimal microbiome and optimal performance. But as you age, nitric oxide production declines—leading to weaker gum health, reduced blood flow, and less vibrant oral health. Furthermore, the use of fluoride toothpastes, antiseptic mouthwashes lead to a loss of nitric oxide production.
That’s why we created the CardioSmile Nitric Oxide Toothpaste—a revolutionary formula designed to boost nitric oxide levels, improve circulation, and support gum health, so you can enjoy a healthier smile every day.
Freshens Breath Boost Nitric Oxide Production
Revitalize a Healthy Oral Microbiome
“We have known for more than 100 years that poor oral hygiene leads to increased risk of cardiovascular disease. Today we know that the oral microbiome responsible for optimizing nitric oxide production accounts for the oral systemic link. Stringent antiseptics, fluoride and poor oral hygiene all disrupt the oral microbiome. Our nitric oxide focused line of oral care products supports the oral microbiome, improving nitric oxide production thereby improving oral and systemic health.”
—Dr. Nathan S. Bryan
International Expert in Nitric Oxide Biochemistry and Physiology
Oral Health
Dr. Nathan Bryan Talks Nitric Oxide on FOX & FRIENDS
Dr. Nathan Bryan joins FOX & FRIENDS to discuss the critical role of nitric oxide in overall health, energy, and longevity.
As a leading expert in the field, Dr. Bryan breaks down how this essential molecule supports circulation, heart health, brain function, and immune support—and why so many people may be unknowingly deficient.
How Nitric Oxide Impacts Your Oral Health
This fluoride-free toothpaste is thoughtfully crafted to support a healthy oral microbiome while boosting nitric oxide production, enhancing gum circulation, and promoting cardiovascular wellness. Its natural remineralizing properties strengthen enamel, offering protection against tooth decay. Perfect for those seeking a clean, fluoride-free alternative, it effectively controls tartar, reduces sensitivity, and supports both oral and overall health. With every use, it leaves your mouth feeling fresh, clean, and revitalized. The only toothpaste targeting the nitric oxide microbiome.
Freshens Breath Naturally
Freshens Breath Naturally
Nitric oxide helps prevent tooth decay by inhibiting the growth of cavity-causing bacteria.
Boost Blood Flow & Circulation
Boost Blood Flow & Circulation
Helps boost circulation for healthier gums and improved cardiovascular function.
Oral Microbiome Support
Oral Microbiome Support
Formulated to nurture a healthy oral microbiome, fostering beneficial bacteria for optimal oral health.
Support Gum Health
Support Gum Health
Nitric oxide supports gum health by promoting blood flow and fighting off harmful bacteria.
Reduce Plaque Build-up
Reduce Plaque Build-up
Nitric oxide helps promote healthy saliva pH and production, which aids in neutralizing acids and reducing plaque buildup.
Elevate Mood & Energy
Elevate Mood & Energy
Feel more vibrant and energized with the natural boost Nitric Oxide provides.
Benefits
Key Benefits
- Fluoride-Free Formula: Natural protection without fluoride.
- Nitric Oxide Support: Enhances circulation for healthier gums and cardiovascular wellness.
- Remineralizes Enamel: Hydroxyapatite strengthens and rebuilds tooth enamel for long-lasting protection.
- Tartar Control: Zinc Citrate helps prevent plaque from hardening into tartar.
- Oral Microbiome Support: Formulated to nurture a healthy oral microbiome, fostering beneficial bacteria for optimal oral health.
- Fights Sensitivity: Potassium Nitrate soothes nerves to reduce tooth sensitivity.
- Freshens Breath Naturally: Peppermint, Spearmint, Wintergreen, and essential oils refresh your mouth while providing antimicrobial benefits.
- Gentle Cleaning: Hydrated Silica and Calcium Carbonate gently polish teeth for a brighter smile.
- No Harsh Chemicals: Formulated with natural, effective ingredients that are safe for you and the environment.
Directions
Directions
Brush thoroughly, at least twice a day, or as directed by a healthcare provider.
Use desired amount on a toothbrush.
Ingredients
Natural & Powerful Ingredients
For Boosting Nitric Oxide And Supporting Oral Health
Nitric Oxide Support
This toothpaste enhances nitric oxide production, which supports blood flow to the gums, helping to promote healthy tissues and may help cardiovascular function. Nitric oxide also plays a vital role in reducing gum inflammation and improving overall oral health.
Nitric Oxide Support
This toothpaste enhances nitric oxide production, which supports blood flow to the gums, helping to promote healthy tissues and may help cardiovascular function. Nitric oxide also plays a vital role in reducing gum inflammation and improving overall oral health.
Fluoride-Free Formula
Free from fluoride, this toothpaste provides natural protection using ingredients like Xylitol and Erythritol, which help reduce harmful bacteria while balancing the beneficial bacteria in your mouth. This supports a healthy oral microbiome and helps prevent cavities—without the use of fluoride.
Fluoride-Free Formula
Free from fluoride, this toothpaste provides natural protection using ingredients like Xylitol and Erythritol, which help reduce harmful bacteria while balancing the beneficial bacteria in your mouth. This supports a healthy oral microbiome and helps prevent cavities—without the use of fluoride.
Tartar Control
Zinc Citrate actively prevents plaque from hardening into tartar, while Hydrated Silica and Calcium Carbonate gently polish teeth, removing surface stains and plaque to maintain a clean and smooth enamel surface.
Tartar Control
Zinc Citrate actively prevents plaque from hardening into tartar, while Hydrated Silica and Calcium Carbonate gently polish teeth, removing surface stains and plaque to maintain a clean and smooth enamel surface.
Oral Microbiome Support
Ingredients such as Xylitol and Erythritol work to reduce harmful bacteria, promoting a balanced microbiome that supports oral health naturally.
Oral Microbiome Support
Ingredients such as Xylitol and Erythritol work to reduce harmful bacteria, promoting a balanced microbiome that supports oral health naturally.
Essential Oils
(Peppermint, Spearmint, Wintergreen, Tea Tree, Cinnamon)
These powerful essential oils provide antimicrobial benefits to fight plaque while freshening breath and soothing gums.
Essential Oils
(Peppermint, Spearmint, Wintergreen, Tea Tree, Cinnamon)
These powerful essential oils provide antimicrobial benefits to fight plaque while freshening breath and soothing gums.
Hydroxyapatite
This fluoride-free alternative helps rebuild and strengthen enamel, providing effective protection against decay while enhancing nitric oxide production to support gum health.
Hydroxyapatite
This fluoride-free alternative helps rebuild and strengthen enamel, providing effective protection against decay while enhancing nitric oxide production to support gum health.
FAQs
Free Shipping for Orders Over $300
Fast Delivery within 2-6 business daysAbout Dr. Bryan
MEET THE FOUNDER
Dr. Nathan Bryan: A Leading Authority on Nitric Oxide
Dr. Nathan S. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Dr. Bryan’s discoveries have led to product and technology innovations that have improved patient care worldwide.
A Pioneer in Nitric Oxide Science
With over 20 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.
A Pioneer in Nitric Oxide Science
With over 20 years of research in cardiovascular health and molecular medicine, Dr. Bryan is one of the world’s foremost experts on Nitric Oxide’s role in human health.
Clinically Backed & Scientifically Proven
His discoveries have shaped the field of Nitric Oxide therapy, leading to cutting-edge solutions like the N1o1 CardioSmile Nitric Oxide Boosting Toothpaste you’re about to experience.
Clinically Backed & Scientifically Proven
His discoveries have shaped the field of Nitric Oxide therapy, leading to cutting-edge solutions like the N1o1 CardioSmile Nitric Oxide Boosting Toothpaste you’re about to experience.
On a Mission to Improve Lives
Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.
On a Mission to Improve Lives
Dr. Bryan is dedicated to helping people unlock their body’s full potential through the power of Nitric Oxide—so they can live longer, healthier, and more vibrant lives.
Research
[1] Oral Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure
PubMed
Nathan S Bryan, Gena Tribble, Nikola Angelov
Department of Molecular and Human Genetics, Baylor College of Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Periodontics, The University of Texas Health Science Center at Houston, 7000 Fannin, Houston, TX, 77030, USA.
Read The Study
[2] The oral microbiome, nitric oxide and exercise performance
PubMed
Nathan S Bryan, Mia C Burleigh, Chris Easton
Nitric Oxide Innovations, LLC, Houston, TX, USA.
Institute for Clinical Exercise and Health Science, University of the West of Scotland, Blantyre, UK.
Download the PDF
[3] Nathan S. Bryan, PhD, points out how using antiseptic mouthwash can reduce good oral bacteria and cause high blood pressure and other conditions.
Dental Sleep Practice
Nathan S Bryan
Read the Study
[4] Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
PubMed
Nathan S Bryan, John W Calvert, John W Elrod, Susheel Gundewar, Sang Yong Ji, David J Lefer
Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA.
Download the PDF
[5] Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults
PubMed
Allison E DeVan, Lawrence C Johnson, Forrest A Brooks, Trent D Evans, Jamie N Justice, Charmion Cruickshank-Quinn, Nichole Reisdorph, Nathan S Bryan, Matthew B McQueen, Jessica R Santos-Parker, Michel B Chonchol, Candace J Bassett, Amy L Sindler, Tony Giordano, Douglas R Seals
- Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado
- Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado
- Integrated Department of Immunology, National Jewish Health, Denver, Colorado
- Baylor College of Medicine, Houston, Texas
- Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado
- TheraVasc, Cleveland, Ohio
[6] Oral nitrite therapy improves vascular function in diabetic mice
PubMed
Amy L Sindler, Kimberly Cox-York, Lauren Reese, Nathan S Bryan, Douglas R Seals, Christopher L Gentile
- Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA Department of Health and Human Physiology, University of Iowa, Iowa City, IA, USA.
- Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
- Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
- Department of Integrative Physiology, University of Colorado, Boulder, Boulder, CO, USA.
- Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA
